The United Nations Convention on the Rights of Persons with Disabilities, adopted on December 13, 2006, and entered into force on May 3, 2008, constitutes a key landmark in the emerging field of global health law and a critical milestone in the development of international law on the rights of persons with disabilities. At the time of its adoption, the U.N. High Commissioner for Human Rights heralded the CRPD as a rejection of the understanding of persons with disabilities “as objects (...) of charity, medical treatment and social protection” and an embrace of disabled people as “subjects of rights.”The text of the Convention itself, and the highly participatory process by which it was negotiated, signal a definitive break from previous international approaches that focused on disability within a medical model framework. In contrast to traditional approaches, the CRPD embraces a social model of disability, concentrating the disability experience not in individual deficiency, but in the socially constructed environment and the barriers that impede the participation of persons with disabilities in society. (shrink)

Mary Taylor, Charlotte Bront"e's closest and lifelong friend, did indeed fulfill Bront"'s prediction in both her life and her writings. Recently, however, the authenticity of Taylor's feminist classic, Miss Miles, has been put into question. A controversy is now raging among experts and scholars of Victorian fiction over the true authorship of Miss Miles. Did Mary Taylor labor over this novel from her early womanhood until the end of her life, and offer it as her last great (...) act of friendship to women? Or is it the last work of Charlotte Bront"e, taken from her home to prevent its destruction, then published posthumously under Taylor's name? Regardless of its authorship, Miss Miles is a passionate and compelling novel, well deserving of its literary status on its own terms, and fascinating as a part of the Bront"e world. In this, the only edition of Miss Miles available, Taylor breaks with tradition by creating a profoundly feminist and morally intense novel which depicts female friendships as sustaining life and samity through the vicissitudes of Victorian womanhood. Set in the small Yorkshire village of Repton against the backdrop of starvation in the wool districts and the rise of Chartism in the 1830s, this extraordinary work chronicles the lives of four socially disparate women as they learn to find their own voices and support one another. Taylor's own courage and allegiance to her friends is wonderfully reflected in each of these individually ambitious women, while the novel's emphasis on the healing power of women's friendships echoes the relationship between Bront"e and Taylor herself. Originally published in 1890, Miss Miles continues to stand as an eloquent polemic in favor of a women's personal obligation to support herself. It is a classic that will delight all lovers of fine literature. (shrink)

First Published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 12.3 (2005) 261-263 [Access article in PDF] The Philosophy of Evil Dan J. Stein Keywords philosophy, evil, self-deception, psychopathy, narcissism, sadism Kubarych (2005) first draws on Peck (1983) to suggest a distinction between psychopaths who have no conscience and therefore no need for self-deception, and evil narcissists who use self-deception to keep the emotional consequences of their crimes out of awareness. He then draws on (...) Davidson (1985) to emphasize a parallel between self-deception (or weakness of the warrant) where an irrational belief conflicts with the evidence, and akrasia (or weakness of the will) where an irrational intention is in conflict with one's values.Although self-deception has long been de-scribed and debated (Fingarette 2000; McLaughlin and Rorty 1988; Mele 2001), a cognitive-affective neuroscience of self-deception has become possible only recently. Such an approach includes several strands. First, contemporary information processing constructs (e.g., schemas) have been used to reframe the early insights of writers like Freud and James, and to emphasize how inattention to painful truths provide a shield against anxiety (Goleman 1997). Second, the theoretical framework of evolutionary psychology has been used to emphasize the adaptive advantages of self-deception (Lockard and Delroy 1988). Third, functional brain imaging studies have noted increased activity in executive regions (e.g., prefrontal and anterior cingulate cortices) during attempted deception but not during truthful responding, suggesting that the former requires active effort (Spence et al. 2004). The functional imaging of memory suppression suggests similar processes (Anderson et al. 2004). To date, however, there has been little functional imaging work on self-deception.Similarly, although evil has always been a key concern of philosophical thought, a cognitive-affective neuroscience of evil has emerged only in recent years (Stein 2000). Evil actions are not homogenous, and this area of research again comprises a number of different strands. First, there are actions where the primary aim is not necessarily to hurt, but where harm is in fact inflicted. (A contested, but perhaps useful example, is the battery-raising of animals for human consumption [Singer 2001]). Second, there are actions where the aim is to hurt, and where harm to the other may even be enjoyed. (During normal altruistic punishment, for example, reward circuitry is activated [de Quervain et al. 2004]). Third, there are actions characterized by impulsive aggression, and a relative absence of executive control. (There may be psychobiological distinctions between reactive aggression in response to frustration or threat, and instrumental aggression that is more goal directed [Blair 2004]).What are the implications of these two sets of cognitive-affective neuroscience literature for a philosophical consideration of evil and of narcissism? [End Page 261] It may be useful to differentiate healthy processes (e.g., having sufficient frontal cortical activity to be able to deceive others) from psychopathologic processes (e.g., not having the necessary frontal-amygdala circuitry required for empathic processing of emotions in social interaction). Similarly, it may be useful to differentiate between normal healthy narcissism (Taylor and Brown 1988) and pathologic malignant narcissism (Kernberg 1985), and between normal altruistic punishment (Hamilton 1963) and pathologic sadistic personality (Kaminer and Stein 2001). In addition, it is perhaps the case that some cognitive-affective processes that do not seem to involve psychopathology may nevertheless be seen as evil (e.g., arguably, the processes that allow a human to eat a battery-raised chicken), whereas some cognitive-affective processes that are clearly psychopathologic may not be viewed as evil (e.g., impulsive aggression in the context of a frontal lobe tumor may be viewed as excusable, as "mad" rather than "bad").Taken together with recent work on the cognitive-affective neuroscience of psychopathy, narcissism, and sadism, these considerations may lead to somewhat different approaches from those taken by Peck and Davidson. In his work on psychopathy, for example, Blair emphasizes a dysfunction in cognitive-affective processing resulting in abnormalities in the weighing up of social emotions (Blair 2004). This account is not inconsistent with a view that in psychopathy there is a disturbance in moral processing that is evil (contra Peck). Furthermore, this... (shrink)

In this paper the exclusive focus on large firms in the field of business ethics is challenged. Some of the idiosyncrasies of small firms are explained, and links are made between these and potential ethical issues. A review of the existing literature on ethics in small firms demonstrates the lack of appropriate research, so that to date we can draw no firm conclusions in relation to ethics in the small firm. Recommendations are made as to the way forward for small (...) firm business ethics research. Questions for investigation are suggested using micro, meso and macro perspectives. Much exploratory work needs to be done to lay the groundwork for this important area of social and commercial research in the future. (shrink)

Many organisms possess multiple sensory systems, such as vision, hearing, touch, smell, and taste. The possession of multiple ways of sensing the world offers many benefits. However, combining information from different senses also poses many challenges for the nervous system. In recent years there has been dramatic progress in understanding how information from the different senses gets integrated in order to construct useful representations of external space. This volume brings together the leading researchers from a broad range of scientific approaches (...) to present the first overview of this central topic in cognitive neuroscience. (shrink)

This article seeks to expand business and society research in a number of ways. Its primary purpose is to redraw two core corporate social responsibility theories, enhancing their relevance for small business. This redrawing is done by the application of the ethic of care, informed by the value of feminist perspectives and the extant empirical research on small business social responsibility. It is proposed that the expanded versions of core theory have wider relevance, value, and implications beyond the small firm (...) context. The theorization of small business social responsibility enables engagement with the mainstream of CSR research as well as making a contribution to small business studies in scholarly, policy, and practice terms. (shrink)

In this paper we report on empirical research which investigates social capital of Small and Medium Sized Enterprises (SMEs). Bringing an international perspective to the work, we make a comparison between 30 firms located in West London and Munich in the sectors of food manufacturing/production, marketing services and garages. Here we present 6 case studies, which we use to illustrate the early findings from this pilot project. We identify differences in approach to associational membership in Germany and the U.K., with (...) a greater propensity to "belong" to an official group in Germany. We distinguish clear sectoral similarities across the countries, and indications that certain personality types will seek out engagement and find time beyond busy work life schedules, often merging work/home/leisure life and friends. Some of our cases illustrate that formal institutions, networks and mutual relationships can develop social capital for the SME, although we should take care not to assume a universal win-win situation for those who are engaged and contribute to the common good. Some of the obstacles to cooperation and civic engagement are outlined. (shrink)

Spence develops and applies a normative model based on rationalist and virtue ethics as well as stoic philosophy to assess the impact of technology on wellbeing. Through developing this model, Spence offers a novel and important examination of the benefit of technology to our society as a whole.

The ‘Molyneux problem’ is typically framed in terms of the crossmodal matching of shape information from touch to vision. Indeed, shape along with intensity have commonly been considered amodal stimulus properties/dimensions (at least by developmental researchers). However, it is important to note that what is common, if anything, to the senses differs in the two cases: It is the physical stimulus (and possibly also the associated phenomenology) that is thought to be the same in the case of crossmodal (or intermodal) (...) shape matching between touch and vision, whereas it is the nature of the underlying neural encoding that is said to be similar in the case of crossmodal matching of auditory and visual stimulus intensity. While the first empirical data to have been published on these two forms of putatively amodal crossmodal matching appeared to suggest that they both emerge surprisingly early in the course of human development (i.e., within the first month of life), certain of these seminal findings have proved difficult to replicate. Ultimately, therefore, there is currently little convincing evidence to support the notion that such putatively innate crossmodal matching of amodal stimulus dimensions is actually different in kind from the various other crossmodal correspondences that are seemingly acquired at various points during the course of human development (typically as a result of the internalization of the crossmodal statistics of the environment). As such, there may be nothing particularly special about the type of crossmodal matching thought to underlie the ‘Molyneux problem’, and continued interest in the issue may inadvertently have helped to sustain a misguided account of the differences between different types of crossmodal correspondence. (shrink)

The law of prior entry was one of E.B. Titchener’s seven fundamental laws of attention. According to Titchener : “the object of attention comes to consciousness more quickly than the objects which we are not attending to.” Although researchers have been studying prior entry for more than a century now, progress in understanding the effect has been hindered by the many methodological confounds present in early research. As a consequence, it is unclear whether the behavioral effects reported in the majority (...) of published studies in this area should be attributed to attention, decisional response biases, and/or, in the case of exogenous spatial cuing studies of the prior-entry effect, to sensory facilitation effects instead. In this article, the literature on the prior-entry effect is reviewed, the confounds present in previous research highlighted, current consensus summarized, and some of the key questions for future research outlined. In particular, recent research has now provided compelling psychophysical and electrophysiological evidence to support the claim that attending to a sensory modality, spatial location, or stimulus feature/attribute can all give rise to a relative speeding-up of the time of arrival of attended, as compared to relatively less attended stimuli. Prior-entry effects have now been demonstrated following both the endogenous and exogenous orienting of attention, though prior-entry effects tend to be smaller in magnitude when assessed by means of participants’ performance on SJ tasks than when assessed by means of their performance on TOJ tasks. (shrink)

The last couple of years have seen a rapid growth of interest in the study of crossmodal correspondences – the tendency for our brains to preferentially associate certain features or dimensions of stimuli across the senses. By now, robust empirical evidence supports the existence of numerous crossmodal correspondences, affecting people’s performance across a wide range of psychological tasks – in everything from the redundant target effect paradigm through to studies of the Implicit Association Test, and from speeded discrimination/classification tasks through (...) to unspeeded spatial localisation and temporal order judgment tasks. However, one question that has yet to receive a satisfactory answer is whether crossmodal correspondences automatically affect people’s performance , as opposed to reflecting more of a strategic, or top-down, phenomenon. Here, we review the latest research on the topic of crossmodal correspondences to have addressed this issue. We argue that answering the question will require researchers to be more precise in terms of defining what exactly automaticity entails. Furthermore, one’s answer to the automaticity question may also hinge on the answer to a second question: Namely, whether crossmodal correspondences are all ‘of a kind’, or whether instead there may be several different kinds of crossmodal mapping . Different answers to the automaticity question may then be revealed depending on the type of correspondence under consideration. We make a number of suggestions for future research that might help to determine just how automatic crossmodal correspondences really are. (shrink)

Use of the terms ‘‘taste’’ and ‘‘flavor’’ is often confusing, both in everyday use and in the academic literature. Failure to distinguish these basic terms can cloud the understanding of the chemical senses, currently a rapidly growing area of study in perception science. The chapter claims that it doesn’t make sense to treat experiences of the putative basic tastes, such as ‘‘sweetness’’ and ‘‘sourness’’ in everyday experience as _tastes_. Rather, the evidence suggests that they should be treated as flavors, just (...) like ‘‘fruity’’ or ‘‘meaty’’. The chapter highlights the confusion between tastes and flavors and outlines reasons for its occurrence, linked to the topics of attention and oral referral. It then provides psychological, physiological, and philosophical reasons for the stance that tastes should be classified as a subcomponent of flavors and shows how doing so helps to dissolve certain debates. (shrink)

If the notion of free will is to be retained by philosophers, psychiatrists and psychologists, then it will be a free will which is essentially non-conscious. The purpose of this paper is to demonstrate that a conscious free will (in the sense of consciousness initiating action) is incompatible with the evidence of neuroscience, and the phenomenology described in the literature of normal creativity, psychotic passivity, and the neurological syndrome of the alien limb or hand. In particular the work of Libet (...) and others who have directly stimulated the brain and measured activity from its surface leads to the conclusion that subjective states (be they sensory or intentional) are preceded by predictive neural activity. Subjective phenomenology is temporally distinct from the initiation of “voluntary” action. In addition it will be argued that free will is more than a belief and that it comprises a perceptual sensorimotor component. Free will is conceptualized as a three component phenomenon consisting of a perceptual, non-linguistic experience of freedom, an experiential belief which is linguistic, and related to a specified action in time, and an abstract belief which is linguistic but remote from any particular action and akin to philosophical discourse (the abstract belief or otherwise, in free will). A theoretical explanation of some of the pathological phenomenology of possession of action is offered in terms of temporal considerations. The direction of action within mental/virtual space is hypothesized to be a function of the temporal sequence of its initiation and awareness of the latter “reaching” consciousness. It is suggested that perturbation of this temporal sequence may lead to the misattribution of host-as-alien-initiated action. Work of this kind, which is beyond subjective introspection, is necessary if we are to develop adequate models to use in conjunction with modern investigation techniques. (shrink)

Are there ‘basic’ tastes and, if so, how many are there? While, to date, this question has mostly been addressed by sensory scientists, it would seem ripe for contemporary philosophical consideration (i.e., after Plato and Aristotle’s early discussion of the matter). Consider only the fact that the majority of those scientists who have written on the subject appear unable to make up their minds as to whether or not umami should be classed as a basic taste, alongside sweet, bitter, sour, (...) and salty. The emergence of various other taste qualities in recent years, such as fatty acid (or ‘oleogustus’) and kokumi, has led (at least one group of) researchers to add another category, namely ‘alimentary’ tastes alongside the so-called basic tastes. Several different lines of evidence have been used to support the existence of basic tastes, including phenomenological (i.e., introspection or perception), cross-cultural linguistic/anthropological, neurophysiological, and neuroimaging data. Perhaps unsurprisingly, though, the answers provided sometimes differ. In this narrative historical review, we critically evaluate the evidence focusing, in particular, on the problematic case of umami, as well as investigating whether an embodied account of basic taste can be supported. Based on the reviewed evidence, we argue for a three-tiered interpretation of ‘basic’, ‘possibly basic’, and ‘ancillary taste qualities’. (shrink)